ZonMW project: How Do Liver Cells Process Cholesterol?

Cholesterol is essential for the body, but its disrupted processing can contribute to diseases such as fatty liver disease, cancer, and neurodegeneration. As part of the ZonMW project ODYSSEUS, Noam Zelcer, Professor of Molecular Regulation of Metabolism, will be investigating how liver cells process cholesterol. Special attention is given to lysosomes—small compartments that function as distribution hubs. The release of cholesterol from lysosomes and its transport to other parts of the cell remains poorly understood. By mapping this process, researchers aim to identify new targets for treating cholesterol-related disorders.

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Latest news Medical Biochemistry Amsterdam

By duda-wsm October 6, 2025
By duda-wsm August 6, 2025
Paper accepted in Current Opinion in Lipidology! Our review article together with Daniel Kober’s group (UTSW) summarizing recent mechanistic and structural findings on the SPRING-S1P-SREBP axis is now out. If you want to understand how this system works have a look. Congrats to Ilaria Micallo and Ashley Bullington for putting this together!
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