Cholesterol is essential for the body, but its disrupted processing can contribute to diseases such as fatty liver disease, cancer, and neurodegeneration. As part of the ZonMW project ODYSSEUS, Noam Zelcer, Professor of Molecular Regulation of Metabolism, will be investigating how liver cells process cholesterol. Special attention is given to lysosomes—small compartments that function as distribution hubs. The release of cholesterol from lysosomes and its transport to other parts of the cell remains poorly understood. By mapping this process, researchers aim to identify new targets for treating cholesterol-related disorders.