VE-cadherin & ARVCF publication in iScience
VE-cadherin interaction proteomics identifies ARVCF as stabilizer of endothelial adherens junctions
How well do we really understand VE-cadherin at endothelial junctions?
Using interaction proteomics, the Huveneers lab found that VE-cadherin binds far more partners than just the classical catenins.
Highlights:
• ARVCF is part of endothelial adherens junctions
• ARVCF stabilizes cell–cell junctions
• It binds a distinct pool of VE-cadherin independent of p120-catenin
The paper by Rianne Schoon et al. also provides a fully open proteomic dataset mapping VE-cadherin interactions.
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