VE-cadherin interaction proteomics identifies ARVCF as stabilizer of endothelial adherens junctions

How well do we really understand VE-cadherin at endothelial junctions?

Using interaction proteomics, the Huveneers lab found that VE-cadherin binds far more partners than just the classical catenins.

Highlights:
• ARVCF is part of endothelial adherens junctions
• ARVCF stabilizes cell–cell junctions
• It binds a distinct pool of VE-cadherin independent of p120-catenin

The paper by Rianne Schoon et al. also provides a fully open proteomic dataset mapping VE-cadherin interactions.