The Zelcer lab's study describing the structure of SPRING and S1P is out. This was a great collaboration with Daniel Kober (UTSW) who is a biochemsitry and CryoEM wizard. This study provides th structural basis for the role SPRING has in proteolytic maturation of the S1P zymogen, and why SPRING is required for S1P-mediated cleavage of the SREBP transcription factors. Enjoy the reading and let us know what you think of this:
https://www.nature.com/articles/s41467-024-50068-8
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Latest news Medical Biochemistry Amsterdam
Project MERCURY is taking off! Prof Noam Zelcer has been awarded an NWO open competition grant to study hepatic APOB metabolism and VLDL production. To do so, innovative proteomic and genetic approaches coupled to in vivo studies will be used to understand how APOB/VLDL is lipidated, trafficked, and secreted in hepatocytes.
At the annual Dutch Atherosclerosis Society (DAS) meeting, Lobke received the award for Best Flash Talk for her presentation on the role of LXR in macrophage immune activation, while Ricky was awarded Best Poster Presentation for his work on the role of IRF1 in macrophage function. Congratulations to both!
