The Zelcer lab's study describing the structure of SPRING and S1P is out. This was a great collaboration with Daniel Kober (UTSW) who is a biochemsitry and CryoEM wizard. This study provides th structural basis for the role SPRING has in proteolytic maturation of the S1P zymogen, and why SPRING is required for S1P-mediated cleavage of the SREBP transcription factors. Enjoy the reading and let us know what you think of this:
https://www.nature.com/articles/s41467-024-50068-8
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Latest news Medical Biochemistry Amsterdam
The yearly AGEM awards were announced: Sebastian Hendrix will receive the AGEM Talent grant which will allow him to develop his project on MASLD. The AGEM innovation grant to study regulation of NPC1 was awarded to team ACHILLES consisting of Klevis Ndoj, Marion Brands, Georges Janssens, and Noam Zelcer.
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