The Zelcer lab's study describing the structure of SPRING and S1P is out. This was a great collaboration with Daniel Kober (UTSW) who is a biochemsitry and CryoEM wizard. This study provides th structural basis for the role SPRING has in proteolytic maturation of the S1P zymogen, and why SPRING is required for S1P-mediated cleavage of the SREBP transcription factors. Enjoy the reading and let us know what you think of this:
https://www.nature.com/articles/s41467-024-50068-8
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Latest news Medical Biochemistry Amsterdam
Paper accepted in Current Opinion in Lipidology! Our review article together with Daniel Kober’s group (UTSW) summarizing recent mechanistic and structural findings on the SPRING-S1P-SREBP axis is now out. If you want to understand how this system works have a look. Congrats to Ilaria Micallo and Ashley Bullington for putting this together!
Biochemical Bulldogs at the Amsterdam UMC football tournament. The football team of the Medical Biochemistry department joined the yearly football tournament at the football fields of FC Abcoude:
