duda-wsm • July 11, 2024
Paper on the structure of SPRING accepted!
The Zelcer lab's study describing the structure of SPRING and S1P is out. This was a great collaboration with Daniel Kober (UTSW) who is a biochemsitry and CryoEM wizard. This study provides th structural basis for the role SPRING has in proteolytic maturation of the S1P zymogen, and why SPRING is required for S1P-mediated cleavage of the SREBP transcription factors. Enjoy the reading and let us know what you think of this:
https://www.nature.com/articles/s41467-024-50068-8
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Latest news Medical Biochemistry Amsterdam
Marten Hoeksema received a Bertus Kemp Stipendium from the " Genootschap ter bevordering van Natuur-, Genees- en Heelkunde ". The aim is to study kinase activity differences in macrophages activated with various cytokines. The grant will be used for this research as well as a work visit to the lab of collaborator dr. Emiel van der Vorst at the university of Aachen.
On Friday, 1st of November, Sebastian Hendrix defended his PhD thesis cum laude describing his work on the role of SPRING in regulating the SREBP pathway and lipid metabolism. The work included in the thesis describes how SREBP is required to promote the maturation of S1P, a protease that is required for the first cleavage-activation event of SREBPs. When SPRING is absent, SREBP cleavage cannot occur and as a consequence the SREBP pathway cannot be activated. The thesis positions SPRING as a core component of the SREBP activation machinery, the only new determinant added in the last 2 decades.
Department of Medical Biochemistry
Amsterdam UMC, location AMC
Meibergdreef 15
1105 AZ Amsterdam
The Netherlands