Deletion of EEPD1 reveals macrophage-specific changes in lipid metabolism and cholesterol efflux
Just in before the PhD defence, Suzanne latest publication on EEPD1 was accepted for publication in “Atherosclerosis” (https://www.atherosclerosis-journal.com/article/S0021-9150(25)00060-7/fulltext). This study describes the metabolic phenotype of mice and macrophages lacking EEPD1. This study reveals that mice lacking EEPD1 are susceptible to weight gain when challenged with a fat containing diet, cements the role of EEPD1 in cholesterol efflux, and identifies marked lipidomic changes in macrophages in the absence of EEPD1.
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Latest news Medical Biochemistry Amsterdam
Another great paper in collaboration on SPRING-S1P with Daniel Kober’s team (UTSW) is bow out in PNAS. Using a neat series of biochemical, structural and cellular studies, Ashley Bullington and Ilaria Micallo studied how the SPRING-S1P complex recognize its substrates and promotes their cleavage. You can get the paper on https://www.pnas.org/doi/full/10.1073/pnas.2426931122 or www.zelcerlab.eu
The AGEM PhD retreat was held on the 3 rd and 4 th of April in Garderen. The theme of the Research Institute was fully centered with interesting presentations by PhDs and guest speakers. Ilaria Micallo, one of our PhD candidates from Noam Zelcer’s group, obtained the Best Poster Award for her research on “Structural basis for substrate selectivity by site-one protease revealed by studies with a small molecule inhibitor” .
