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After previously already obtaining the Veni and Vidi awards, Stephan is now awarded the prestigious Vici award from ZonMW: 1.5 million euros for excellent research from the Netherlands Organization for Scientific Research (NWO). He will receive this Vici grant to develop an innovative research line over the next 5 years and to further expand his own research group.

With this Vici grant, Stephan aims to find ways to prevent blood vessel leakage during illness. Endothelial cells in the blood vessel wall are closely connected to each other via molecular connections. It has recently been discovered that so-called 'signals' ensure that these compounds maintain their strength, even if, for example, blood pressure changes. These cohesion-strengthening proteins protect the blood vessels, because the cells in the blood vessel wall remain connected to each other even under pressure.

However, in patients with vascular diseases, such as high blood pressure, these connections between the cells of the blood vessel wall become damaged and the blood vessels start to leak. Stephan and his team will study how endothelial cells respond to tension and stiffness. The knowledge gained is then used to look for ways to prevent blood vessel leakage during disease.

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Latest news Medical Biochemistry Amsterdam

By duda-wsm February 11, 2025
UvA Synergy Program Awarded to Vascular Immunology Research Consortium An interdisciplinary team of researchers from the Faculty of Medicine (FdG) and the Faculty of Science (FNWI) has been awarded a synergy grant from UvA to advance groundbreaking research in vascular immunology. The multidisciplinary team aims to bridge the gap between fundamental science and clinical application, translating basic scientific discoveries into clinical practice and refining clinical insights into laboratory research. The Synergy Program This synergy program led by ACS researcher Professor Jaap van Buul represents a unique opportunity to bridge the gap between fundamental research and clinical practice. Key objectives of the program include using vascular dysfunction as a predictor for inflammatory-related disease risk, identifying molecular and cellular targets, and developing tailored therapies to restore vascular immunology. The grant The grant funds six PhD positions and a senior postdoc position shared between the faculties of Sciences and Medicine. The program also aims to foster interdisciplinary master's and PhD training programs to equip the next generation of scientists with expertise spanning both faculties. Interested to know more? The program will launch with an inaugural symposium this Fall titled " You are as healthy as your vessels ". 
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