On Friday, 1st of November, Sebastian Hendrix defended his PhD thesis cum laude describing his work on the role of SPRING in regulating the SREBP pathway and lipid metabolism. The work included in the thesis describes how SREBP is required to promote the maturation of S1P, a protease that is required for the first cleavage-activation event of SREBPs. When SPRING is absent, SREBP cleavage cannot occur and as a consequence the SREBP pathway cannot be activated. The thesis positions SPRING as a core component of the SREBP activation machinery, the only new determinant added in the last 2 decades.
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Latest news Medical Biochemistry Amsterdam
Another great paper in collaboration on SPRING-S1P with Daniel Kober’s team (UTSW) is bow out in PNAS. Using a neat series of biochemical, structural and cellular studies, Ashley Bullington and Ilaria Micallo studied how the SPRING-S1P complex recognize its substrates and promotes their cleavage. You can get the paper on https://www.pnas.org/doi/full/10.1073/pnas.2426931122 or www.zelcerlab.eu
The AGEM PhD retreat was held on the 3 rd and 4 th of April in Garderen. The theme of the Research Institute was fully centered with interesting presentations by PhDs and guest speakers. Ilaria Micallo, one of our PhD candidates from Noam Zelcer’s group, obtained the Best Poster Award for her research on “Structural basis for substrate selectivity by site-one protease revealed by studies with a small molecule inhibitor” .
