Apolipoprotein B (APOB)-containing very LDL (VLDL) production, secretion, and clearance by hepatocytes is a central determinant of hepatic and circulating lipid levels. Impairment of any of the aforementioned processes is associated with the development of multiple diseases. Despite the discovery of genes and processes that govern hepatic VLDL metabolism, our understanding of the different mechanistic steps involved is far from complete. An impediment to these studies is the lack of tractable hepatocyte-based systems to interrogate and follow APOB in cells, which the current study addresses.


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Latest news Medical Biochemistry Amsterdam

By duda-wsm August 6, 2025
Paper accepted in Current Opinion in Lipidology! Our review article together with Daniel Kober’s group (UTSW) summarizing recent mechanistic and structural findings on the SPRING-S1P-SREBP axis is now out. If you want to understand how this system works have a look. Congrats to Ilaria Micallo and Ashley Bullington for putting this together!
By duda-wsm July 11, 2025
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