Apolipoprotein B (APOB)-containing very LDL (VLDL) production, secretion, and clearance by hepatocytes is a central determinant of hepatic and circulating lipid levels. Impairment of any of the aforementioned processes is associated with the development of multiple diseases. Despite the discovery of genes and processes that govern hepatic VLDL metabolism, our understanding of the different mechanistic steps involved is far from complete. An impediment to these studies is the lack of tractable hepatocyte-based systems to interrogate and follow APOB in cells, which the current study addresses.


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Latest news Medical Biochemistry Amsterdam

By duda-wsm April 8, 2025
The AGEM PhD retreat was held on the 3 rd and 4 th of April in Garderen. The theme of the Research Institute was fully centered with interesting presentations by PhDs and guest speakers. Ilaria Micallo, one of our PhD candidates from Noam Zelcer’s group, obtained the Best Poster Award for her research on “Structural basis for substrate selectivity by site-one protease revealed by studies with a small molecule inhibitor” .
By duda-wsm March 26, 2025
Karen and Panos got awarded the Amsterdam UMC Young Talent Fund . This fund awards young PhD talents a chance to further develop and enhance their skills, with the aim to provide the opportunity for PhD candidates to do an internship or follow a course at top international research institutes.
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